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Diagnosis of toxoplasmosis:
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  • Easy-to-use platform
  • Mother and child safety
  • 3 markers - IgG, IgM, Avidity - to answer all diagnostic guidelines for pregnancy follow-up

Toxoplasmosis in short…

Toxoplasmosis is due to an obligate intracellular protozoan parasite called Toxoplasma gondii and is very prevalent in humans (in some countries, more than 50% of the population is infected). Toxoplasmosis is generally very mild in the immunocompetent host, but it can be severe in fetuses in cases of congenital infection, as well as in immunosuppressed patients.

Toxoplasmosis is asymptomatic or paucisymptomatic in more than 80% of cases. Diagnosis of acute infection is mainly based on serological testing prescribed in the following clinical situations:

  • When the patient is symptomatic and confirmation of the diagnosis is needed
  • In pregnant women

bioMérieux: Historical
leader in the diagnosis of Toxoplasmosis

 

1969

 

Launch of the first Toxoplasmosis detection kit

    Did you know?

    IgG is widely used to determine the presence of specific immunity.

    • Unlike false negative results, false positives can have severe consequences.

    If IgM appears earlier than IgG, it also disappears earlier. This makes IgM an early and sensitive marker of acute infection.

    • The first quality of an IgM test is sensitivity, but IgM can persist for over 6 months and sometimes even for years (residual IgM).

    Serology is not always clear-cut. Reactivation, reinfection, polyclonal stimulation, residual IgM andnon-specific IgM can lead to unnecessary treatment, amniocentesis, abortion and distress.

    • The Solution = Avidity.
    • Right from the first sample collection, avidity measurement excludes most recent infections. However, confirmation on a 2nd sample is recommended.

     

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      VIDAS® TOXO: Join them!

      VIDAS® TOXO: Optimal performance, supported by evidence

      "Vidas avidity exhibited better performance than Architect avidity"

      "Vidas […] displayed excellent performance for IgG and IgM detection"

      "The Vidas system adequately detects toxoplasmosis in pregnant women and newborns. This system fits the needs of laboratories working on small routine series for first-line testing as well as expert laboratories, due to a high specificity and a powerful avidity test. […] The Vidas system provides better Se (sensitivity) in screening for both IgG and IgM in pregnant women than the Liaison and Architect assays."

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          1. Jenum PA, Stray-Pedersen B, Gundersen AG. Improved diagnosis of primary Toxoplasma gondii infection in early pregnancy by determination of antitoxoplasma immunoglobulin G avidity. J Clin Microbiol. 1997;35:1972-7.

          2. Wilson M, Remington JS. Clavet C, et al. Evaluation of six commercial kits for detection of human immunoglobulin M antibodies to Toxoplasma gondii. The FDA Toxoplasmosis Ad Hoc Working Group. J Clin Microbiol. 1997;35:3112-15.

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